Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours

Aslan Mansurov, Jun Ishihara, Peyman Hosseinchi, +9

Nature Biomedical Engineering

InflammationCytokineCancer ImmunosurveillanceCold Mouse TumoursImmunology +8

Targeted antibody and cytokine cancer immunotherapies through collagen affinity

Jun Ishihara, Ako Ishihara, Koichi Sasaki, +15

Science Translational Medicine

Recruitment of CD103 ⁺ dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy

John‐Michael Williford, Jun Ishihara, Ako Ishihara, +6

Science Advances

Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker

Aslan Mansurov, Peyman Hosseinchi, Kevin Chang, +14

Nature Biomedical Engineering

InflammationCytokineCancer ImmunosurveillanceTumour-protease-cleavable LinkerImmunology +8

Engineered collagen-binding serum albumin as a drug conjugate carrier for cancer therapy

Koichi Sasaki, Jun Ishihara, Ako Ishihara, +4

Science Advances

Cancer TherapyEngineeringImmunologyCollagen-binding Serum AlbuminBiomedical Engineering +22

Bacterial Adhesion to Ultrafiltration Membranes: Role of Hydrophilicity, Natural Organic Matter, and Cell-Surface Macromolecules

Sara BinAhmed, Anissa Hasane, Zhaoxing Wang, +2

Environmental Science & Technology

Adhesion Contact TimeMembrane FormationPolymer MembraneUltrafiltration MembranesMedicine +10

Targeting inflammatory sites through collagen affinity enhances the therapeutic efficacy of anti-inflammatory antibodies

Kiyomitsu Katsumata, Jun Ishihara, Aslan Mansurov, +4

Science Advances

Inflammatory Lung DiseaseCollagen AffinityLung InflammationImmunologyPathology +24

Prolonged residence of an albumin–IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis

Ako Ishihara, Jun Ishihara, Elyse A. Watkins, +14

Nature Biomedical Engineering

ImmunologyImmune RegulationPathologyAlbumin–il-4 Fusion ProteinCd4 T Cell Responses +14

Polymersomes Decorated with the SARS-CoV-2 Spike Protein Receptor-Binding Domain Elicit Robust Humoral and Cellular Immunity

Lisa R. Volpatti, Rachel P. Wallace, Shijie Cao, +27

ACS Central Science

Suppression of Rheumatoid Arthritis by Enhanced Lymph Node Trafficking of Engineered Interleukin‐10 in Murine Models

Eiji Yuba, Erica Budina, Kiyomitsu Katsumata, +13

Arthritis & Rheumatology