Concepedia

Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker

Aslan Mansurov, Peyman Hosseinchi, Kevin Chang, Abigail L. Lauterbach, Laura Gray, Aaron T. Alpar, Erica Budina, Anna J. Slezak, Seounghun Kang, Shijie Cao,

Nature Biomedical Engineering · 2022 · 94 citations · 42 references

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42

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Sanjeev Mariathasan, Shannon J. Turley, Dorothee Nickles et al. · Nature · 2018 · 5.5K citations

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IFN-γ–related mRNA profile predicts clinical response to PD-1 blockade

Mark Ayers, Jared Lunceford, Michael Nebozhyn et al. · Journal of Clinical Investigation · 2017 · 3.9K citations · Full text

, , +17

Cooperation between Constitutive and Inducible Chemokines Enables T Cell Engraftment and Immune Attack in Solid Tumors

Marine Bruand, Alizée J Grimm, Catherine Ronet et al. · Cancer Cell · 2019 · 910 citations · Full text

, , +14

Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production.

John P. Leonard, Matthew L. Sherman, Gerald L. Fisher et al. · PubMed · 1997 · 814 citations

, , +16

Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advanced malignancies.

Michael B. Atkins, Michael J. Robertson, Michael S. Gordon et al. · PubMed · 1997 · 590 citations

, , +15