Laminin heparin-binding peptides bind to several growth factors and enhance diabetic wound healing

Jun Ishihara, Ako Ishihara, Kazuto Fukunaga, +4

Nature Communications

Collagen-binding IL-12 enhances tumour inflammation and drives the complete remission of established immunologically cold mouse tumours

Aslan Mansurov, Jun Ishihara, Peyman Hosseinchi, +9

Nature Biomedical Engineering

InflammationCytokineCancer ImmunosurveillanceCold Mouse TumoursImmunology +8

Targeted antibody and cytokine cancer immunotherapies through collagen affinity

Jun Ishihara, Ako Ishihara, Koichi Sasaki, +15

Science Translational Medicine

Matrix-binding checkpoint immunotherapies enhance antitumor efficacy and reduce adverse events

Jun Ishihara, Kazuto Fukunaga, Ako Ishihara, +6

Science Translational Medicine

Recruitment of CD103 ⁺ dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy

John‐Michael Williford, Jun Ishihara, Ako Ishihara, +6

Science Advances

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing

Jun Ishihara, Ako Ishihara, Richard Starke, +10

Blood

Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy

Vipul Bhatia, Nikhil Kamat, Tiffany E. Pariva, +21

Nature Communications

Antigen-dependent IL-12 signaling in CAR T cells promotes regional to systemic disease targeting

Eric Hee Jun Lee, John P. Murad, Lea Christian, +22

Nature Communications

Masking the immunotoxicity of interleukin-12 by fusing it with a domain of its receptor via a tumour-protease-cleavable linker

Aslan Mansurov, Peyman Hosseinchi, Kevin Chang, +14

Nature Biomedical Engineering

InflammationCytokineCancer ImmunosurveillanceTumour-protease-cleavable LinkerImmunology +8

Engineered collagen-binding serum albumin as a drug conjugate carrier for cancer therapy

Koichi Sasaki, Jun Ishihara, Ako Ishihara, +4

Science Advances

Cancer TherapyEngineeringImmunologyCollagen-binding Serum AlbuminBiomedical Engineering +22