Brendan Horton

Tumor-Residing Batf3 Dendritic Cells Are Required for Effector T Cell Trafficking and Adoptive T Cell Therapy

Stefani Spranger, Daisy Dai, Brendan Horton et al. · Cancer Cell · 2017 · 1.4K citations · Full text

Life Sciences, Immunology, Oncology +14

Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment

Stefani Spranger, Holly K. Koblish, Brendan Horton et al. · Journal for ImmunoTherapy of Cancer · 2014 · 545 citations · Full text

Life Sciences, Immunology, Oncology +17

The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment

Jason B. Williams, Brendan Horton, Yan Zheng et al. · The Journal of Experimental Medicine · 2017 · 209 citations · Full text

Medicine, Immunology, Oncology +17

Intratumoral CD8+ T-cell Apoptosis Is a Major Component of T-cell Dysfunction and Impedes Antitumor Immunity

Brendan Horton, Jason B. Williams, Alexandra Cabanov et al. · Cancer Immunology Research · 2017 · 164 citations · Full text

Life Sciences, Immunology, Oncology +17

Tissue-specific abundance of interferon-gamma drives regulatory T cells to restrain DC1-mediated priming of cytotoxic T cells against lung cancer

Maria Zagorulya, Leon Yim, Duncan M. Morgan et al. · Immunity · 2023 · 148 citations · Full text

Life Sciences, Cancer Biology, Immunology +15