CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence

Analyzing real-time PCR data by the comparative CT method

Thomas D. Schmittgen, Kenneth J. Livak · Nature Protocols · 2008 · 26K citations

Computed Tomography, Image Analysis, Engineering +8

The serial cultivation of human diploid cell strains

Leonard Hayflick, Paul S. Moorhead · Experimental Cell Research · 1961 · 8.3K citations

Human Cell, Cell Division, Genetics +5

Extension of Life-Span by Introduction of Telomerase into Normal Human Cells

Andrea Bodnár, Michel Ouellette, Maria Frolkis et al. · Science · 1998 · 4.9K citations

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

Jean‐Philippe Coppé · 2008 · 4K citations · Full text

Oncogenic Ras, Health Sciences, Medicine +13

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

Darren J. Baker, Tobias Wijshake, Tamar Tchkonia et al. · Nature · 2011 · 3.5K citations · Full text

Aging, P16ink4a-positive Senescent Cells, Immunology +6