Concepedia

Aconitase 2 inhibits the proliferation of MCF-7 cells promoting mitochondrial oxidative metabolism and ROS/FoxO1-mediated autophagic response

Fabio Ciccarone, Luca Di Leo, Giacomo Lazzarino, Giuseppe Maulucci, Flavio Di Giacinto, Barbara Tavazzi, Maria Rosa Ciriolo

British Journal of Cancer · 2019 · 65 citations · 60 references

DOIFull text

Open access

Abstract

This work identifies ACO2 as a relevant gene in cancer metabolic rewiring of MCF-7 cells, promoting a different utilisation of pyruvate and revealing the potential metabolic vulnerability of ACO2-associated malignancies.

References

60

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An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients

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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.7K citations · Full text

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