Concepedia

FoxO3 reverses 5-fluorouracil resistance in human colorectal cancer cells by inhibiting the Nrf2/TR1 signaling pathway

Chao Liu, Yan Zhao, Jianing Wang, Yan Yang, Yan Zhang, Xinliang Qu, Sishi Peng, Zhaoying Yao, Shuli Zhao, Bangshun He,

Cancer Letters · 2019 · 67 citations · 37 references

DOI

Concepts

References

37

Global patterns and trends in colorectal cancer incidence and mortality

Melina Arnold, Mónica S. Sierra, Mathieu Laversanne et al. · Gut · 2016 · 5.3K citations · Full text

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Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Ken Itoh, Nobunao Wakabayashi, Yasutake Katoh et al. · Genes & Development · 1999 · 3.6K citations · Full text

, , +16

Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2

Akira Kobayashi, Moon-Il Kang, Hiromi Okawa et al. · Molecular and Cellular Biology · 2004 · 2.2K citations · Full text

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Distinct Cysteine Residues in Keap1 Are Required for Keap1-Dependent Ubiquitination of Nrf2 and for Stabilization of Nrf2 by Chemopreventive Agents and Oxidative Stress

Donna D. Zhang, Mark Hannink · Molecular and Cellular Biology · 2003 · 1.4K citations · Full text

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Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents.

P M O'Connor, Joany Jackman, I Bae et al. · PubMed · 1997 · 882 citations

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