mAbs · 2019 · 16 citations · 29 references
Life SciencesBiochemistryBiologyMolecular VirologyStructural BiologyVirologyAntibody CharacterizationAntibody StructureAntibody-antigen RecognitionLigand BindingProtein ConformationProtein StructureAnalytical CharacterizationAnalytical Size-exclusion ChromatographyAntibody Binding SpecificityAntibody Binding ThermodynamicsAntibody-antigen Binding KineticsComplementarity-determining Region 3Conformational EquilibriumSize-exclusion Liquid Chromatography
conformers with the membrane-proximal ectodomain region epitope in the GP41 antigen. Altogether, these results reveal at mechanistic and molecular levels the effect of proline isomerization in the CDR on the antibody binding and analytical profiles, and support further development of the trispecific anti-HIV antibody.
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VMD: Visual molecular dynamics
William Humphrey, Andrew Dalke, Klaus Schulten · Journal of Molecular Graphics · 1996 · 66.6K citations
Scalable molecular dynamics with NAMD
J. C. Phillips, Rosemary Braun, Wei Wang et al. · Journal of Computational Chemistry · 2005 · 17.4K citations · Full text
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
Xueling Wu, Zhi-Yong Yang, Yuxing Li et al. · Science · 2010 · 1.8K citations