Concepedia

IL‐17C amplifies epithelial inflammation in human psoriasis and atopic eczema

Felix Lauffer, Manja Jargosch, V. Baghin, Linda Krause, W. Kempf, Magdalena Absmaier-Kijak, Martina Morelli, Stefania Madonna, Florence Marsais, L. Lepescheux,

Journal of the European Academy of Dermatology and Venereology · 2019 · 47 citations · 16 references

DOIFull text

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Abstract

IL-17C amplifies epithelial inflammation in Th2 and Th17 dominated skin inflammation and represents a promising target for the treatment of ISD.

References

16

Quantification of histochemical staining by color deconvolution.

Arnout Ruifrok, D. A. Johnston · PubMed · 2001 · 2.1K citations

IL-23 stimulates epidermal hyperplasia via TNF and IL-20R2–dependent mechanisms with implications for psoriasis pathogenesis

Jason R. Chan, Wendy M. Blumenschein, Erin Murphy et al. · The Journal of Experimental Medicine · 2006 · 669 citations · Full text

, , +16

Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis

Mei Li, Pierre Hener, Zhikun Zhang et al. · Proceedings of the National Academy of Sciences · 2006 · 522 citations · Full text

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IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

Vladimir Ramirez-Carrozzi, Arivazhagan Sambandam, Elizabeth Luis et al. · Nature Immunology · 2011 · 454 citations

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IL-17RE is the functional receptor for IL-17C and mediates mucosal immunity to infection with intestinal pathogens

Xinyang Song, Shu Zhu, Peiqing Shi et al. · Nature Immunology · 2011 · 312 citations

, , +7