Novel antibody–antibiotic conjugate eliminates intracellular S. aureus

Sophie M. Lehar, Thomas H. Pillow, Min Xu, +29

Nature

Antimicrobial Drug DiscoveryAntimicrobial SusceptibilityAntibioticsMedicineMicrobiology +5

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

Vladimir Ramirez-Carrozzi, Arivazhagan Sambandam, Elizabeth Luis, +19

Nature Immunology

InflammationCytokineInnate Immune FunctionInnate Immune SystemImmunology +9

Membrane-Proximal Epitope Facilitates Efficient T Cell Synapse Formation by Anti-FcRH5/CD3 and Is a Requirement for Myeloma Cell Killing

Ji Li, Nicola J. Stagg, Jennifer Johnston, +21

Cancer Cell

Synapse FormationImmunologyImmunoeditingCell DeathImmunologic Mechanism +14

Robo4 Maintains Vessel Integrity and Inhibits Angiogenesis by Interacting with UNC5B

Alexander Koch, Thomas Mathivet, Bruno Larrivée, +21

Developmental Cell

Inhibits AngiogenesisAngiogenesisVascular AdaptationEndothelial DysfunctionVascular Biology +6

Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1

Ai-Luen Wu, Ganesh Kolumam, Scott Stawicki, +20

Science Translational Medicine

InflammationSignal TransductionGrowth HormoneBrown Adipose TissuesDiabetes +11

Antitumor Efficacy of a Bispecific Antibody That Targets HER2 and Activates T Cells

Teemu T. Junttila, Ji Li, Jennifer Johnston, +20

Cancer Research

Molecular basis for negative regulation of the glucagon receptor

Christopher M. Koth, Jeremy Murray, Susmith Mukund, +11

Proceedings of the National Academy of Sciences

Crystal StructureMolecular PhysiologySignal TransductionBiochemistryGlucagon Receptor Inhibition +13

EphB2 as a Therapeutic Antibody Drug Target for the Treatment of Colorectal Cancer

Weiguang Mao, Elizabeth Luis, Sarajane Ross, +8

Cancer Research

Antibodies specific for a segment of human membrane IgE deplete IgE-producing B cells in humanized mice

Hans D. Brightbill, Surinder Jeet, Zhonghua Lin, +24

Journal of Clinical Investigation

AsthmaHumoral ResponseImmunologyAntigen ProcessingImmunotherapy +16

Sustained Brown Fat Stimulation and Insulin Sensitization by a Humanized Bispecific Antibody Agonist for Fibroblast Growth Factor Receptor 1/βKlotho Complex

Ganesh Kolumam, Mark Z. Chen, Raymond K. Tong, +36

EBioMedicine