Concepedia

Amelioration of Type 2 Diabetes by Antibody-Mediated Activation of Fibroblast Growth Factor Receptor 1

Ai-Luen Wu, Ganesh Kolumam, Scott Stawicki, Yongmei Chen, Jun Li, Jose Zavala‐Solorio, Khanhky Phamluong, Bo Feng, Li Li, Scot A. Marsters,

Science Translational Medicine · 2011 · 172 citations · 29 references

DOI

Concepts

Abstract

Antibody-mediated activation of fibroblast growth factor receptor 1 reverses the diabetic phenotype in mice, likely by affecting brown adipose tissues.

References

29

FGF-21 as a novel metabolic regulator

Alexei Kharitonenkov, Tatiyana L. Shiyanova, Anja Köester et al. · Journal of Clinical Investigation · 2005 · 2.1K citations · Full text

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Endocrine Regulation of the Fasting Response by PPARα-Mediated Induction of Fibroblast Growth Factor 21

Takeshi Inagaki, Paul A. Dutchak, Guixiang Zhao et al. · Cell Metabolism · 2007 · 1.5K citations · Full text

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Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

Michael K. Badman, Pavlos Pissios, Adam R. Kennedy et al. · Cell Metabolism · 2007 · 1.5K citations · Full text

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CREB regulates hepatic gluconeogenesis through the coactivator PGC-1

Stephan Herzig, Fanxin Long, Ulupi S. Jhala et al. · Nature · 2001 · 1.4K citations

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Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity

Yong‐Xu Wang, Chih‐Hao Lee, Sambath Tiep et al. · Cell · 2003 · 1.3K citations · Full text

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