Concepedia

Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis

Melanie Fritsch, Saskia Diana Günther, Robin Schwarzer, Marie‐Christine Albert, Fabian Schorn, J Paul Werthenbach, Lars M. Schiffmann, Neil Stair, Hannah Stocks, Jens M. Seeger,

Nature · 2019 · 1.1K citations · 28 references

DOI

Concepts

References

28

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

Marta Muzio, Arul M. Chinnaiyan, Frank Kischkel et al. · Cell · 1996 · 3.1K citations · Full text

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Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

Mark Boldin, Tanya Goncharov, Yury V Goltseve et al. · Cell · 1996 · 2.3K citations · Full text

, , +12

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

Andrew Oberst, Christopher P. Dillon, Ricardo Weinlich et al. · Nature · 2011 · 1.3K citations

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Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

Eugene Varfolomeev, Marcus Schuchmann, Victor Luria et al. · Immunity · 1998 · 1.2K citations · Full text

, , +16

RIP3 mediates the embryonic lethality of caspase-8-deficient mice

William J. Kaiser, Jason W. Upton, Alyssa B. Long et al. · Nature · 2011 · 1K citations

, , +14