Concepedia

Heterotropic activation of flavonoids on cytochrome P450 3A4: A case example of alleviating dronedarone-induced cytotoxicity

Jie Bai, Li Li, Shengyu Zhao, Xiaoqing Fan, Jie Zhang, Minwan Hu, Yonghui Chen, Yanhong Sun, Baolian Wang, Jing Jin,

Toxicology Letters · 2019 · 22 citations · 22 references

DOI

Concepts

References

22

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Linda B. Moore, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2000 · 938 citations

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Evaluation of Atypical Cytochrome P450 Kinetics with Two-Substrate Models:  Evidence That Multiple Substrates Can Simultaneously Bind to Cytochrome P450 Active Sites

Ken Korzekwa, N. Krishnamachary, Magang Shou et al. · Biochemistry · 1998 · 519 citations

, , +17

Elucidation of Distinct Ligand Binding Sites for Cytochrome P450 3A4

Natilie Hosea, Grover P. Miller, F. Peter Guengerich · Biochemistry · 2000 · 223 citations

, , +17

Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4

Irina F. Sevrioukova, T.L. Poulos · Proceedings of the National Academy of Sciences · 2016 · 108 citations · Full text

, , +17

Flavonoids diosmetin and luteolin inhibit midazolam metabolism by human liver microsomes and recombinant CYP 3A4 and CYP3A5 enzymes

Luigi Quintieri, Pietro Palatini, Alberto Nassi et al. · Biochemical Pharmacology · 2007 · 98 citations

, , +14