Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis

Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis

Rie Watanabe‐Fukunaga, Camilynn I. Brannan, Neal G. Copeland et al. · Nature · 1992 · 2.9K citations

Life Sciences, Immunology, Pathology +14

Fas triggers an alternative, caspase-8–independent cell death pathway using the kinase RIP as effector molecule

Nils Holler, Rossana Zaru, Olivier Micheau et al. · Nature Immunology · 2000 · 1.9K citations

Life Sciences, Cell Biology, Molecular Biology +14

Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis

Andrew Oberst, Christopher P. Dillon, Ricardo Weinlich et al. · Nature · 2011 · 1.3K citations

Life Sciences, Biochemistry, Molecular Biology +12

Targeted Disruption of the Mouse Caspase 8 Gene Ablates Cell Death Induction by the TNF Receptors, Fas/Apo1, and DR3 and Is Lethal Prenatally

Eugene Varfolomeev, Marcus Schuchmann, Victor Luria et al. · Immunity · 1998 · 1.2K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +16

The Pseudokinase MLKL Mediates Necroptosis via a Molecular Switch Mechanism

James M. Murphy, Peter E. Czabotar, Joanne M. Hildebrand et al. · Immunity · 2013 · 1.2K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +13