Concepedia

Curcumin Regulates the Progression of Colorectal Cancer via LncRNA NBR2/AMPK Pathway

Hua Yu, Yangyang Xie, Zhendong Zhou, Wu Zhou, Xiaoyu Dai, Binbin Xu

Technology in Cancer Research & Treatment · 2019 · 50 citations · 17 references

DOIFull text

Open access

Abstract

This study revealed a novel mechanism by which long noncoding RNA NBR2 mediates curcumin suppression of colorectal cancer proliferation by activating adenosine monophosphate-activated protein kinase and inactivating the mTOR signaling pathway.

References

17

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Dana M. Gwinn, David B. Shackelford, Daniel F. Egan et al. · Molecular Cell · 2008 · 3.7K citations · Full text

, , +5

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

Maria M. Mihaylova, Reuben J. Shaw · Nature Cell Biology · 2011 · 2.9K citations · Full text

, , +12

The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer

Wei-Cheng Liang, Wei-ming Fu, Cheuk-Wa Wong et al. · Oncotarget · 2015 · 581 citations · Full text

Curcumin regulates miR-21 expression and inhibits invasion and metastasis in colorectal cancer

Giridhar Mudduluru, Jonahunnatha Nesson George-William, Santoshi Muppala et al. · Bioscience Reports · 2010 · 328 citations · Full text

, , +15

LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress

Xiaowen Liu, Zhen‐Dong Xiao, Leng Han et al. · Nature Cell Biology · 2016 · 282 citations

, , +10