A method to determine BPA, BPB, and BPF levels in fruit juices by liquid chromatography coupled to tandem mass spectrometry

Abstract

The monitoring of the contamination levels of bisphenol A (BPA) and its congeners bisphenol B (BPB) and bisphenol F (BPF) in foodstuffs is a necessary process for assessment of consumers' risk. After development and validation of a method using Strata® C18-E cartridge cleanup with detection by liquid chromatography coupled to tandem mass spectrometry, forty-six samples of fruit juices, sold on Italian markets, have been analysed to assess the concentration of BPA, BPB and BPF. BPB and BPF were not detected in any samples, BPA was found in 33 % of the samples. The observed levels ranged from 0.50 ng mL^-1 to 2.85 ng mL^-1. Potential Daily Intakes (PDI) of BPA for Italian populations were calculated by the budget method model. PDIs ranged from 0.012 to 0.285 μg kg^-1 bw day^-1. None of the calculated values exceeded the current temporary TDI of 4 μg kg^-1 bw day^-1.