A cryptic hydrophobic pocket in the polo-box domain of the polo-like kinase PLK1 regulates substrate recognition and mitotic chromosome segregation

Evaluation and Reparametrization of the OPLS-AA Force Field for Proteins via Comparison with Accurate Quantum Chemical Calculations on Peptides

George A. Kaminski, Richard A. Friesner, Julian Tirado‐Rives et al. · The Journal of Physical Chemistry B · 2001 · 4K citations

Engineering, Biochemistry, Protein Folding +15

BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo

Martin Steegmaier, Matthias Hoffmann, Anke Baum et al. · Current Biology · 2007 · 839 citations · Full text

Tumor Biology, Bi 2536, Medicine +9

The Molecular Basis for Phosphodependent Substrate Targeting and Regulation of Plks by the Polo-Box Domain

Andrew E. H. Elia, Peter Rellos, L.F. Haire et al. · Cell · 2003 · 763 citations · Full text

Polo-box Domain, Protein Function, Signal Transduction +12

Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.

Heidi A. Lane, Erich A. Nigg · The Journal of Cell Biology · 1996 · 689 citations · Full text

Cell Proliferation, Cytoskeleton, Cell Cycle +20

Proteomic Screen Finds pSer/pThr-Binding Domain Localizing Plk1 to Mitotic Substrates

Andrew E. H. Elia, Lewis C. Cantley, Michael B. Yaffe · Science · 2003 · 679 citations

Signal Recognition, Molecular Biology, Mitotic Substrates +16