Concepedia

The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia

Christophe Lechauve, Julia Keith, Eugene Khandros, Stephanie Fowler, Kalin Mayberry, Abdullah Freiwan, Christopher S. Thom, Paola Delbini, Emilio Boada-Romero, Jingjing Zhang,

Science Translational Medicine · 2019 · 62 citations · 47 references

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Abstract

cells of β-thalassemic individuals. Our findings define a drug-regulatable pathway for ameliorating β-thalassemia.

References

47

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin, Ignacio Arganda‐Carreras, Erwin Frise et al. · Nature Methods · 2012 · 70.9K citations

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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Joungmok Kim, Mondira Kundu, Benoı̂t Viollet et al. · Nature Cell Biology · 2011 · 7K citations · Full text

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Taichi Hara, Kenji Nakamura, Makoto Matsui et al. · Nature · 2006 · 3.8K citations

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Trainable Weka Segmentation: a machine learning tool for microscopy pixel classification

Ignacio Arganda‐Carreras, Verena Kaynig, Curtis Rueden et al. · Bioinformatics · 2017 · 2.5K citations

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Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

Nao Hosokawa, Taichi Hara, Takeshi Kaizuka et al. · Molecular Biology of the Cell · 2009 · 2K citations · Full text

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