Base editing of haematopoietic stem cells rescues sickle cell disease in mice

Gregory A. Newby, Jonathan Yen, Kaitly J. Woodard, +26

Nature

Base EditingCell TherapyHaematopoietic Stem CellsMedicineStem Cell Transplantation +7

Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss

Hélène Cwerman‐Thibault, Sébastien Augustin, Christophe Lechauve, +4

Molecular Therapy — Methods & Clinical Development

The crystal structure of wild-type human brain neuroglobin reveals flexibility of the disulfide bond that regulates oxygen affinity

B.G. Guimarães, Djemel Hamdane, Christophe Lechauve, +2

Acta Crystallographica Section D Biological Crystallography

Crystal StructureHuman NeuroglobinMolecular BiologyRedox BiologyCd Region +14

Neuroglobin involvement in respiratory chain function and retinal ganglion cell integrity

Christophe Lechauve, Sébastien Augustin, Hélène Cwerman‐Thibault, +7

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Ganglion CellRetinaOphthalmologyNeurophysiologyNeuroanatomy +9

The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia

Christophe Lechauve, Julia Keith, Eugene Khandros, +12

Science Translational Medicine

Cytoglobin conformations and disulfide bond formation

Christophe Lechauve, Cédric Chauvierre, Sylvia Dewilde, +5

FEBS Journal

Cytoglobin conformations and disulfide bond formation

Christophe Lechauve, Cédric Chauvierre, Sylvia Dewilde, +5

FEBS Journal

Protein ChemistryDistal HistidineProtein AssemblyBiochemistryProtein Folding +11

Genotypic and Phenotypic Characterization of P23H Line 1 Rat Model

Elise Orhan, Deniz Dalkara, Marion Neuillé, +9

PLoS ONE

Ocular DiseaseMammalian PhysiologyGeneticsMolecular GeneticsOptogenetics +15

Regulation of gene expression by miR-144/451 during mouse erythropoiesis

Peng Xu, Lance E. Palmer, Christophe Lechauve, +11

Blood

Endothelial cell α-globin and its molecular chaperone α-hemoglobin–stabilizing protein regulate arteriolar contractility

Christophe Lechauve, Joshua T. Butcher, Abdullah Freiwan, +8

Journal of Clinical Investigation