Christophe Lechauve

Base editing of haematopoietic stem cells rescues sickle cell disease in mice

Gregory A. Newby, Jonathan Yen, Kaitly J. Woodard et al. · Nature · 2021 · 353 citations · Full text

Base Editing, Cell Therapy, Haematopoietic Stem Cells +9

Nuclear expression of mitochondrial ND4 leads to the protein assembling in complex I and prevents optic atrophy and visual loss

Hélène Cwerman‐Thibault, Sébastien Augustin, Christophe Lechauve et al. · Molecular Therapy — Methods & Clinical Development · 2015 · 80 citations · Full text

The crystal structure of wild-type human brain neuroglobin reveals flexibility of the disulfide bond that regulates oxygen affinity

B.G. Guimarães, Djemel Hamdane, Christophe Lechauve et al. · Acta Crystallographica Section D Biological Crystallography · 2014 · 69 citations · Full text

Crystal Structure, Human Neuroglobin, Molecular Biology +16

Neuroglobin involvement in respiratory chain function and retinal ganglion cell integrity

Christophe Lechauve, Sébastien Augustin, Hélène Cwerman‐Thibault et al. · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · 2012 · 61 citations

Ganglion Cell, Retina, Ophthalmology +11

The autophagy-activating kinase ULK1 mediates clearance of free α-globin in β-thalassemia

Christophe Lechauve, Julia Keith, Eugene Khandros et al. · Science Translational Medicine · 2019 · 61 citations · Full text