Jonathan Yen

Directed evolution of adenine base editors with increased activity and therapeutic application

Nicole M. Gaudelli, Dieter K. Lam, Holly A. Rees et al. · Nature Biotechnology · 2020 · 505 citations

Medicinal Chemistry, Pharmaceutical Chemistry, Biochemistry +10

Butyrate Greatly Enhances Derivation of Human Induced Pluripotent Stem Cells by Promoting Epigenetic Remodeling and the Expression of Pluripotency-Associated Genes

Prashant Mali, Bin-Kuan Chou, Jonathan Yen et al. · Stem Cells · 2010 · 414 citations · Full text

Selective in vivo metabolic cell-labeling-mediated cancer targeting

Hua Wang, Ruibo Wang, Kaimin Cai et al. · Nature Chemical Biology · 2017 · 365 citations · Full text

Tumor Biology, Medicine, Cancer Biology +6

Base editing of haematopoietic stem cells rescues sickle cell disease in mice

Gregory A. Newby, Jonathan Yen, Kaitly J. Woodard et al. · Nature · 2021 · 353 citations · Full text

Base Editing, Cell Therapy, Haematopoietic Stem Cells +9

Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice

Kelcee A. Everette, Gregory A. Newby, Rachel M. Levine et al. · Nature Biomedical Engineering · 2023 · 125 citations · Full text