Concepedia

PLP-dependent enzymes as important biocatalysts for the pharmaceutical, chemical and food industries: a structural and mechanistic perspective

Juliana F. Rocha, André F. Pina, Sérgio F. Sousa, Nuno M. F. S. A. Cerqueira

Catalysis Science & Technology · 2019 · 102 citations · 86 references

DOI

Concepts

Abstract

PLP-dependent enzymes described on this review are attractive targets for enzyme engineering towards their application in an industrial biotechnology framework.

References

86

Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture

Christopher K. Savile, Jacob M. Janey, Emily C. Mundorff et al. · Science · 2010 · 1.7K citations

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Biocatalytic Approaches to the Synthesis of Enantiomerically Pure Chiral Amines

Diego Ghislieri, Nicholas J. Turner · Topics in Catalysis · 2013 · 421 citations · Full text

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Biocatalytic Routes to Optically Active Amines

Matthias Höhne, Uwe T. Bornscheuer · ChemCatChem · 2009 · 383 citations

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Evolutionary relationships among pyridoxal‐5′‐phosphate‐dependent enzymes

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, , +15

Rational assignment of key motifs for function guides in silico enzyme identification

Matthias Höhne, Sebastian Schätzle, Helge Jochens et al. · Nature Chemical Biology · 2010 · 369 citations

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