Concepedia

Structure-based Enzyme Engineering

Structure-Based Enzyme Engineering is a computational and experimental methodology that belongs to the class of enzyme design approaches, distinguished by its reliance on atomic-resolution structural data of enzyme-substrate complexes to rationally modify active site architecture and stabilize transition state intermediates for enhanced catalytic efficiency.

286

Publications

19.3K

Citations

1.6K

Authors

484

Institutions

Publications per year

2017–2026

140

Parents

Publications

286

Kemp elimination catalysts by computational enzyme design

Daniela Röthlisberger, Olga Khersonsky, Andrew M. Wollacott et al. · Nature · 2008 · 1.3K citations

, , +14

Improving catalytic function by ProSAR-driven enzyme evolution

Richard J. Fox, Sarah C. Davis, Emily C. Mundorff et al. · Nature Biotechnology · 2007 · 552 citations

, , +14

Multi-enzyme complexes on DNA scaffolds capable of substrate channelling with an artificial swinging arm

Jinglin Fu, Yuhe R. Yang, Alexander Johnson‐Buck et al. · Nature Nanotechnology · 2014 · 494 citations

, , +17

Machine Learning in Enzyme Engineering

Stanislav Mazurenko, Zbyněk Prokop · ACS Catalysis · 2019 · 420 citations · Full text

, , +17

Artificial Enzymes Formed through Directed Assembly of Molecular Square Encapsulated Epoxidation Catalysts

Melissa L. Merlau, Maria del Pilar Mejia, SonBinh T. Nguyen et al. · Angewandte Chemie International Edition · 2001 · 392 citations

, , +17

1–5 of 286

Authors

1.6K

  1. CC
    Chun‐Chi Chen

    Chinese Academy of Sciences, China

    6 publications · 394 citations

    6

    h-index

  2. DB
    David Baker

    University of Washington, United States

    6 publications · 2.1K citations

    6

    h-index

  3. WL
    Weidong Liu

    Chinese Academy of Sciences, China

    6 publications · 343 citations

    6

    h-index

  4. RG
    Rey‐Ting Guo

    Tianjin Institute of Industrial Biotechnology, China

    6 publications · 375 citations

    6

    h-index

  5. VG
    Vı́ctor Guallar

    Universitat Politècnica de Catalunya, Spain

    5 publications · 148 citations

    5

    h-index

1–5 of 1.6K

Institutions

484

  1. Chinese Academy of Sciences

    Beijing, China

    22 h-index

    100 publications

    6.7K citations

  2. Jiangnan University

    Wuxi, China

    14 h-index

    68 publications

    2.7K citations

  3. Tianjin Institute of Industrial Biotechnology

    Tianjin, China

    11 h-index

    56 publications

    2.5K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    33 publications

    1.2K citations

  5. University of Washington

    Seattle, United States

    7 h-index

    24 publications

    8.3K citations

  6. Imperial College London

    London, United Kingdom

    6 h-index

    18 publications

    3.1K citations

  7. East China University of Science and Technology

    Shanghai, China

    6 h-index

    32 publications

    757 citations

  8. Howard Hughes Medical Institute

    Chevy Chase, United States

    6 h-index

    12 publications

    4.7K citations

1–8 of 484

Venues

  1. ACS Catalysis

    26 publications · 1.9K citations

    24

    h-index

  2. Journal of the American Chemical Society

    JACS · 14 publications · 1.2K citations

    14

    h-index

  3. Angewandte Chemie International Edition

    13 publications · 940 citations

    11

    h-index

  4. Protein Engineering Design and Selection

    PEDS · 10 publications · 338 citations

    10

    h-index

  5. Nature Communications

    10 publications · 753 citations

    10

    h-index

1–5