Concepedia

Transition State Stabilization

Transition State Stabilization is a mechanism of enzymatic catalysis whereby an enzyme lowers the activation free energy of a reaction by preferentially binding and stabilizing the transition state relative to the ground-state substrates and products, typically through optimally arranged noncovalent interactions.

331

Publications

18.7K

Citations

1K

Authors

353

Institutions

Publications per year

2017–2026

41

Parents

Children

Publications

331

Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

J.J.G. Tesmer, David M. Berman, Alfred G. Gilman et al. · Cell · 1997 · 788 citations · Full text

, , +13

Glycosidase mechanisms: anatomy of a finely tuned catalyst.

David L. Zechel, Stephen G. Withers · Accounts of Chemical Research · 2000 · 698 citations

, , +16

Energetics of enzyme catalysis.

Arieh Warshel · Proceedings of the National Academy of Sciences · 1978 · 491 citations · Full text

, , +17

Thermodynamic control of asymmetric amplification in amino acid catalysis

Hiroshi Iwamura, Suju Mathew, David H. Wells et al. · Nature · 2006 · 396 citations

, , +16

Subtilisin. Stereochemical mechanism involving transition-state stabilization

Jon D. Robertus, Joseph Kraut, Richard A. Alden et al. · Biochemistry · 1972 · 377 citations

, , +7

1–5 of 331

Authors

1K

  1. JP
    John P. Richard

    University at Buffalo, State University of New York, United States

    18 publications · 713 citations

    15

    h-index

  2. TL
    Tina L. Amyes

    University at Buffalo, State University of New York, United States

    15 publications · 526 citations

    15

    h-index

  3. RW
    Richard Wolfenden

    University of North Carolina at Chapel Hill, United States

    7 publications · 447 citations

    7

    h-index

  4. AJ
    Adrian J. Mulholland

    University of Bristol, United Kingdom

    6 publications · 438 citations

    6

    h-index

  5. AW
    Arieh Warshel

    University of Southern California, United States

    6 publications · 920 citations

    6

    h-index

1–5 of 1K

Institutions

353

  1. University at Buffalo, State University of New York

    Buffalo, United States

    16 h-index

    68 publications

    2.6K citations

  2. Centre National de la Recherche Scientifique

    Paris, France

    10 h-index

    39 publications

    1.3K citations

  3. University of Illinois Urbana-Champaign

    Urbana, United States

    9 h-index

    29 publications

    985 citations

  4. University of Wisconsin–Madison

    Madison, United States

    7 h-index

    18 publications

    707 citations

  5. Pennsylvania State University

    State College, United States

    6 h-index

    13 publications

    721 citations

  6. University of Bristol

    Bristol, United Kingdom

    6 h-index

    23 publications

    1.9K citations

  7. Universitat Jaume I

    Castellon, Spain

    6 h-index

    15 publications

    493 citations

  8. Albert Einstein College of Medicine

    Bronx, United States

    6 h-index

    13 publications

    1.4K citations

1–8 of 353

Venues

  1. Journal of the American Chemical Society

    JACS · 53 publications · 3.3K citations

    34

    h-index

  2. Biochemistry

    42 publications · 2.6K citations

    29

    h-index

  3. Journal of Molecular Biology

    JMB · 15 publications · 1.1K citations

    14

    h-index

  4. Proceedings of the National Academy of Sciences

    PNAS · 13 publications · 1.4K citations

    12

    h-index

  5. The Journal of Organic Chemistry

    JOC · 14 publications · 501 citations

    12

    h-index

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