Concepedia

Enzyme Electrostatics

Enzyme Electrostatics is a theoretical framework within the study of transition state stabilization that characterizes the role of electrostatic interactions in modulating enzyme catalytic efficiency by stabilizing charged transition states through precisely oriented dipoles, ion pairs, and electric fields within the active site.

284

Publications

20K

Citations

939

Authors

339

Institutions

Publications per year

2017–2026

41

Parents

Publications

284

Theoretical studies of enzymic reactions: Dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme

Arieh Warshel, Michael Levitt · Journal of Molecular Biology · 1976 · 4.5K citations

, , +17

Calculation of the electric potential in the active site cleft due to α-helix dipoles

Jim Warwicker, H.C. Watson · Journal of Molecular Biology · 1982 · 934 citations

, , +12

Extreme electric fields power catalysis in the active site of ketosteroid isomerase

Stephen D. Fried, Sayan Bagchi, Steven G. Boxer · Science · 2014 · 600 citations

, , +17

Energetics of enzyme catalysis.

Arieh Warshel · Proceedings of the National Academy of Sciences · 1978 · 491 citations · Full text

, , +17

Calculation of electrostatic potentials in an enzyme active site

Michael K. Gilson, Barry Honig · Nature · 1987 · 447 citations

, , +14

1–5 of 284

Authors

939

  1. JA
    J. Andrew McCammon

    University of California San Diego, United States

    16 publications · 1.2K citations

    15

    h-index

  2. SG
    Steven G. Boxer

    Stanford University, United States

    16 publications · 2K citations

    14

    h-index

  3. AW
    Arieh Warshel

    University of Southern California, United States

    11 publications · 5.8K citations

    11

    h-index

  4. JA
    Jan Antosiewicz

    University of Warsaw, Poland

    6 publications · 232 citations

    6

    h-index

  5. GN
    Gábor Náray‐Szabó

    Eötvös Loránd University, Hungary

    6 publications · 138 citations

    6

    h-index

1–5 of 939

Institutions

339

  1. Stanford University

    Stanford, United States

    15 h-index

    52 publications

    6.4K citations

  2. University of California San Diego

    San Diego, United States

    11 h-index

    27 publications

    1.9K citations

  3. University of Southern California

    Los Angeles, United States

    9 h-index

    30 publications

    2.2K citations

  4. University of Rome Tor Vergata

    Rome, Italy

    6 h-index

    21 publications

    443 citations

  5. Albert Einstein College of Medicine

    Bronx, United States

    5 h-index

    8 publications

    330 citations

  6. University of Houston

    Houston, United States

    5 h-index

    14 publications

    759 citations

  7. University of Cambridge

    Cambridge, United Kingdom

    5 h-index

    25 publications

    1K citations

  8. Universitat de València

    Valencia, Spain

    5 h-index

    14 publications

    410 citations

1–8 of 339

Venues

  1. Biochemistry

    33 publications · 1.4K citations

    23

    h-index

  2. Journal of the American Chemical Society

    JACS · 25 publications · 1.7K citations

    22

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 20 publications · 2.4K citations

    20

    h-index

  4. Journal of Molecular Biology

    JMB · 11 publications · 6K citations

    11

    h-index

  5. Proteins Structure Function and Bioinformatics

    12 publications · 339 citations

    11

    h-index

1–5