David L. Zechel

Glycosidase mechanisms: anatomy of a finely tuned catalyst.

David L. Zechel, Stephen G. Withers · Accounts of Chemical Research · 2000 · 698 citations

Life Sciences, Biochemistry, Biocatalysis +16

Iminosugar Glycosidase Inhibitors:  Structural and Thermodynamic Dissection of the Binding of Isofagomine and 1-Deoxynojirimycin to β-Glucosidases

David L. Zechel, A.B. Boraston, T.M. Gloster et al. · Journal of the American Chemical Society · 2003 · 169 citations

Life Sciences, Biochemistry, Medicinal Chemistry +15

An automated Genomes-to-Natural Products platform (GNP) for the discovery of modular natural products

Chad W. Johnston, Michael A. Skinnider, Morgan A. Wyatt et al. · Nature Communications · 2015 · 142 citations · Full text

Pharmacy, Bioinformatics, Biotechnology +17

Glycosidase Inhibition:  An Assessment of the Binding of 18 Putative Transition-State Mimics

T.M. Gloster, Peter J. Meloncelli, Robert V. Stick et al. · Journal of the American Chemical Society · 2007 · 138 citations

Pharmacy, Biochemistry, Medicinal Chemistry +17

Substrate Distortion by a -Mannanase: Snapshots of the Michaelis and Covalent-Intermediate Complexes Suggest a B2,5 Conformation for the Transition State

V.M.-A. Ducros, David L. Zechel, Garib N. Murshudov et al. · Angewandte Chemie International Edition · 2002 · 131 citations

Life Sciences, Biochemistry, Molecular Biology +14