Anti-inflammatory effect of artemisinin on uric acid-induced NLRP3 inflammasome activation through blocking interaction between NLRP3 and NEK7

Gout-associated uric acid crystals activate the NALP3 inflammasome

Fabio Martinon, Virginie Pétrilli, Annick Mayor et al. · Nature · 2006 · 5.2K citations

Life Sciences, Cell Biology, Immunology +11

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae et al. · Nature Medicine · 2015 · 2.8K citations · Full text

Life Sciences, Immunology, Medicinal Chemistry +15

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Raúl Muñoz-Planillo, Peter Kuffa, Giovanny J. Martínez-Colón et al. · Immunity · 2013 · 2.1K citations

Life Sciences, Immunology, Microbiology +16

Preliminary criteria for the classification of the acute arthritis of primary gout

Stanley L. Wallace, Harry Robinson, Alfonse T. Masi et al. · Arthritis & Rheumatism · 1977 · 1.4K citations

Medicine, Clinical Sciences, Internal Medicine +13

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

Virginie Pétrilli, Stéphanie Papin, Catherine Dostert et al. · Cell Death and Differentiation · 2007 · 1.4K citations

Life Sciences, Cell Biology, Immunology +10