Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes

Genome engineering using the CRISPR-Cas9 system

F. Ann Ran, Patrick D. Hsu, Jason Wright et al. · Nature Protocols · 2013 · 11.4K citations · Full text

Engineering, Genome Surgery, Genetics +7

Computer Visualization of Three-Dimensional Image Data Using IMOD

James R. Kremer, David N. Mastronarde, J. Richard McIntosh · Journal of Structural Biology · 1996 · 5.9K citations

Geometric Modeling, Real-time Visualization, Engineering +5

p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death

Geir Bjørkøy, Trond Lamark, Andreas Brech et al. · The Journal of Cell Biology · 2005 · 3.2K citations · Full text

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

Sven Bergmann, Gert‐Jan B. van Ommen · Nature Genetics · 2010 · 2.9K citations · Full text

Obesity, Genome-wide Association Study, Body Composition +11

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

Yasemin Sancak, Timothy R. Peterson, Yoav D. Shaul et al. · Science · 2008 · 2.7K citations · Full text