Concepedia

Insulin Degradation

Insulin Degradation is a biochemical process within the broader category of hormone inactivation that specifically involves the enzymatic breakdown of insulin primarily in the liver and kidneys, distinguishing it from other hormonal deactivation mechanisms by its reliance on insulin-degrading enzyme (IDE) and lysosomal proteolysis.

819

Publications

42.4K

Citations

2.6K

Authors

703

Institutions

Publications per year

2017–2026

61

Parents

Publications

819

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain <i>in vivo</i>

Wesley Farris, Stefan Mansourian, Yang Chang et al. · Proceedings of the National Academy of Sciences · 2003 · 1.5K citations · Full text

, , +15

Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

Wei Qiao Qiu, Dominic M. Walsh, Zhen Ye et al. · Journal of Biological Chemistry · 1998 · 800 citations · Full text

, , +17

Insulin gene mutations as a cause of permanent neonatal diabetes

Julie Støy, Emma L. Edghill, Sarah E. Flanagan et al. · Proceedings of the National Academy of Sciences · 2007 · 557 citations · Full text

, , +16

Receptor-Mediated Transport of Insulin Across Endothelial Cells

George L. King, Sandra Marchese Johnson · Science · 1985 · 473 citations

, , +11

Solid‐Phase Edman Degradation

Richard A. Laursen · European Journal of Biochemistry · 1971 · 427 citations · Full text

, , +15

1–5 of 819

Authors

2.6K

  1. WC
    William C. Duckworth

    University of Nebraska Medical Center, United States

    48 publications · 2.4K citations

    32

    h-index

  2. FG
    Frederick G. Hamel

    University of Nebraska Medical Center, United States

    28 publications · 1.3K citations

    21

    h-index

  3. MR
    Marsha Rich Rosner

    University of Chicago, United States

    20 publications · 2K citations

    18

    h-index

  4. RA
    Richard A. Roth

    Stanford University, United States

    17 publications · 976 citations

    17

    h-index

  5. PT
    Partab T. Varandani

    Antioch College, United States

    21 publications · 718 citations

    16

    h-index

1–5 of 2.6K

Institutions

703

  1. University of Chicago

    Chicago, United States

    26 h-index

    117 publications

    17.4K citations

  2. University of Nebraska Medical Center

    Omaha, United States

    20 h-index

    75 publications

    3.7K citations

  3. Stanford University

    Stanford, United States

    19 h-index

    82 publications

    3.3K citations

  4. University of Tennessee Health Science Center

    Memphis, United States

    18 h-index

    52 publications

    2.5K citations

  5. May Institute

    Randolph, United States

    17 h-index

    52 publications

    4.8K citations

  6. Kobe University

    Kobe, Japan

    15 h-index

    81 publications

    3K citations

  7. United States Department of Veterans Affairs

    Washington, United States

    14 h-index

    45 publications

    1.3K citations

  8. Inserm

    Paris, France

    14 h-index

    57 publications

    2.6K citations

1–8 of 703

Venues

  1. Journal of Biological Chemistry

    JBC · 84 publications · 7.7K citations

    51

    h-index

  2. Diabetes

    96 publications · 3.4K citations

    36

    h-index

  3. Endocrinology

    65 publications · 2.4K citations

    32

    h-index

  4. PubMed

    Repository · 35 publications · 1.4K citations

    19

    h-index

  5. Biochemical and Biophysical Research Communications

    BBRC · 24 publications · 951 citations

    18

    h-index

1–5