Design, synthesis and biological evaluation of novel perimidine o-quinone derivatives as non-intercalative topoisomerase II catalytic inhibitors

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

Tim R. Mosmann · Journal of Immunological Methods · 1983 · 54.9K citations

Cellular Growth, Rapid Colorimetric Assay, Cytotoxicity Assays +11

Inhibition of topoisomerase II by antitumor agents bis(2,6-dioxopiperazine) derivatives.

K Tanabe, Yoji Ikegami, Ryoji Ishida et al. · PubMed · 1991 · 297 citations

Molecular Pharmacology, Medicinal Chemistry, Pharmaceutical Chemistry +14

New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure–Activity Relationship Analysis and Biological Evaluations

Guoqiang Dong, Shengzheng Wang, Zhenyuan Miao et al. · Journal of Medicinal Chemistry · 2012 · 179 citations

Pharmaceutical Science, Old Natural Product, Novel Antitumor Agents +17

Structure-antitumor activity relationships among quinone derivatives.

Driscoll Js, Hazard Gf, Wood Hb et al. · PubMed · 1974 · 85 citations

Medicinal Chemistry, Derivative (Chemistry), Biochemistry +7

Synthesis of pharmacologically important naphthoquinones and anticancer activity of 2-benzyllawsone through DNA topoisomerase-II inhibition

B. Sathish Kumar, Kusumoori Ravi, Amit Verma et al. · Bioorganic & Medicinal Chemistry · 2016 · 81 citations

Medicinal Chemistry, Pharmaceutical Chemistry, Biochemistry +10