Zhenyuan Miao

Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents

Shengzheng Wang, Kun Fang, Guoqiang Dong et al. · Journal of Medicinal Chemistry · 2015 · 189 citations · Full text

Medicinal Chemistry, Natural Product Synthesis, Diversity Oriented Synthesis +13

Structure-Based Optimization of Azole Antifungal Agents by CoMFA, CoMSIA, and Molecular Docking

Chunquan Sheng, Wannian Zhang, Haitao Ji et al. · Journal of Medicinal Chemistry · 2006 · 182 citations

New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure–Activity Relationship Analysis and Biological Evaluations

Guoqiang Dong, Shengzheng Wang, Zhenyuan Miao et al. · Journal of Medicinal Chemistry · 2012 · 179 citations

Pharmaceutical Science, Old Natural Product, Novel Antitumor Agents +17

Selection of Evodiamine as a Novel Topoisomerase I Inhibitor by Structure-Based Virtual Screening and Hit Optimization of Evodiamine Derivatives as Antitumor Agents

Guoqiang Dong, Chunquan Sheng, Shengzheng Wang et al. · Journal of Medicinal Chemistry · 2010 · 145 citations

Pharmaceutical Science, Bioorganic Chemistry, Chemoprevention Strategy +19

Discovery, Synthesis, and Biological Evaluation of Orally Active Pyrrolidone Derivatives as Novel Inhibitors of p53–MDM2 Protein–Protein Interaction

Chunlin Zhuang, Zhenyuan Miao, Lingjian Zhu et al. · Journal of Medicinal Chemistry · 2012 · 128 citations

Pharmacotherapy, Chemistry, Chemical Biology +19