Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents

Shengzheng Wang, Kun Fang, Guoqiang Dong, +7

Journal of Medicinal Chemistry

Medicinal ChemistryNatural Product SynthesisDiversity Oriented SynthesisBiochemistryMedicine +11

Structure-Based Optimization of Azole Antifungal Agents by CoMFA, CoMSIA, and Molecular Docking

Chunquan Sheng, Wannian Zhang, Haitao Ji, +10

Journal of Medicinal Chemistry

New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure–Activity Relationship Analysis and Biological Evaluations

Guoqiang Dong, Shengzheng Wang, Zhenyuan Miao, +5

Journal of Medicinal Chemistry

Pharmaceutical ScienceOld Natural ProductNovel Antitumor AgentsPharmacotherapyPharmaceutical Chemistry +15

Selection of Evodiamine as a Novel Topoisomerase I Inhibitor by Structure-Based Virtual Screening and Hit Optimization of Evodiamine Derivatives as Antitumor Agents

Guoqiang Dong, Chunquan Sheng, Shengzheng Wang, +3

Journal of Medicinal Chemistry

Pharmaceutical ScienceBioorganic ChemistryChemoprevention StrategyPharmacotherapyPharmaceutical Chemistry +17

Discovery, Synthesis, and Biological Evaluation of Orally Active Pyrrolidone Derivatives as Novel Inhibitors of p53–MDM2 Protein–Protein Interaction

Chunlin Zhuang, Zhenyuan Miao, Lingjian Zhu, +8

Journal of Medicinal Chemistry

PharmacotherapyChemistryChemical BiologyPharmaceutical ChemistryMedicinal Chemistry +17

Three-Dimensional Model of Lanosterol 14α-Demethylase from <i>Cryptococcus neoformans</i> : Active-Site Characterization and Insights into Azole Binding

Chunquan Sheng, Zhenyuan Miao, Haitao Ji, +7

Antimicrobial Agents and Chemotherapy

Molecular BiologyChemical BiologyDrug ResistanceThree-dimensional ModelAzole Binding +16

Meeting Organocatalysis with Drug Discovery: Asymmetric Synthesis of 3,3′-Spirooxindoles Fused with Tetrahydrothiopyrans as Novel p53-MDM2 Inhibitors

Shengzheng Wang, Yan Jiang, Shanchao Wu, +4

Organic Letters

Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains

Zhigan Jiang, Julin Gu, Chen Wang, +10

European Journal of Medicinal Chemistry

Medicinal ChemistryNovel Triazole DerivativesDerivativesDerivative (Chemistry)Antifungal Activity +9

Divergent Cascade Construction of Skeletally Diverse “Privileged” Pyrazole‐Derived Molecular Architectures

Yongqiang Zhang, Shanchao Wu, Shengzheng Wang, +9

European Journal of Organic Chemistry

EngineeringMolecular BiologyOrganic ChemistryChemistryMolecular Design +19

Discovery of Novel Multiacting Topoisomerase I/II and Histone Deacetylase Inhibitors

Shipeng He, Guoqiang Dong, Zhibin Wang, +9

ACS Medicinal Chemistry Letters

Hdac InhibitorsTriple Topoisomerase I/iiChemoprevention StrategyMolecular BiologyPharmacotherapy +16