Concepedia

Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice

Maura Poli, Ferdous Anower-E-Khuda, Michela Asperti, Paola Ruzzenenti, Magdalena Gryzik, Andrea Denardo, Philip L.S.M. Gordts, Paolo Arosio, Jeffrey D. Esko

Journal of Biological Chemistry · 2019 · 26 citations · 38 references

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Abstract

These results provide compelling evidence that hepatocyte heparan sulfate plays a key role in regulating hepcidin expression and iron homeostasis in mice and in human hepatocytes.

References

38

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