Concepedia

Early Clearance of Mycobacterium tuberculosis: The INFECT Case Contact Cohort Study in Indonesia

Ayesha J Verrall, Bachti Alisjahbana, Lika Apriani, Novianty Novianty, Andini C Nurani, Arjan van Laarhoven, James E. Ussher, Agnes Rengga Indrati, Rovina Ruslami, Mihai G. Netea,

The Journal of Infectious Diseases · 2019 · 71 citations · 21 references

DOI

Abstract

A quarter of household TB case contacts were early clearers. Protection against M. tuberculosis infection was strongly associated with BCG vaccination. Lower protection from BCG with increasing M. tuberculosis exposure and age can inform vaccine development.

References

21

Global tuberculosis report (2014)

L.A. Gabbasova, E.R. Experts Who · 2014 · 13.2K citations

, , +6

Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Johanneke Kleinnijenhuis, Jessica Quintin, Frank Preijers et al. · Proceedings of the National Academy of Sciences · 2012 · 1.7K citations · Full text

, , +30

BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis

Eva Kaufmann, Joaquín Sanz, Jonathan L. Dunn et al. · Cell · 2018 · 1.1K citations · Full text

, , +4

Prevention of <i>M. tuberculosis</i> Infection with H4:IC31 Vaccine or BCG Revaccination

Elisa Nemes, Hennie Geldenhuys, Virginie Rozot et al. · New England Journal of Medicine · 2018 · 650 citations · Full text

Immunometabolic Pathways in BCG-Induced Trained Immunity

Rob J.W. Arts, Agostinho Carvalho, Claudia La Rocca et al. · Cell Reports · 2016 · 625 citations · Full text