Concepedia

Concept

trained immunity

Parents

157

Publications

18.9K

Citations

1.1K

Authors

344

Institutions

About

Trained immunity is an academic concept and research field investigating the ability of the innate immune system to develop long-term memory after initial exposure to certain stimuli, leading to an enhanced, non-specific response to subsequent infections or challenges. This concept explores the epigenetic, metabolic, and functional reprogramming of innate immune cells, such as monocytes, macrophages, and NK cells, which results in a heightened state of readiness and altered cytokine production upon re-stimulation. Its significance lies in expanding the understanding of immune memory beyond the adaptive immune system and its potential for developing new prophylactic and therapeutic strategies targeting innate immune responses.

Top Authors

Rankings shown are based on concept H-Index.

MG

Radboud University Nijmegen

LA

Radboud University Nijmegen

SJ

Radboud University Nijmegen

JD

Radboud University Nijmegen

JV

Radboud University Nijmegen

Top Institutions

Rankings shown are based on concept H-Index.

Radboud University Nijmegen

Nijmegen, The Netherlands

Radboud University Medical Center

Nijmegen, The Netherlands

University of Bonn

Bonn, Germany

Broad Institute

Cambridge, United States

Harvard University

Cambridge, United States

Top Venues

Rankings shown are based on concept H-Index.

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