Concepedia

Trained Immunity

Trained Immunity is a form of innate immune memory characterized by enhanced responsiveness of innate immune cells to subsequent challenges following an initial stimulus, distinguishing it from classical immunological memory by its lack of antigen specificity and reliance on epigenetic, metabolic, and functional reprogramming of myeloid cells.

228

Publications

28.2K

Citations

1.6K

Authors

511

Institutions

Publications per year

2017–2026

204

Variants

Innate Immune Memory

Parents

Children

Publications

228

mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

Shih‐Chin Cheng, Jessica Quintin, Robert A. Cramer et al. · Science · 2014 · 2.1K citations

, , +17

Bacille Calmette-Guérin induces NOD2-dependent nonspecific protection from reinfection via epigenetic reprogramming of monocytes

Johanneke Kleinnijenhuis, Jessica Quintin, Frank Preijers et al. · Proceedings of the National Academy of Sciences · 2012 · 1.7K citations · Full text

, , +17

Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

Sadia Saeed, Jessica Quintin, Hindrik H. D. Kerstens et al. · Science · 2014 · 1.7K citations

, , +17

BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity

Rob J.W. Arts, Simone J.C.F.M. Moorlag, Boris Novakovic et al. · Cell Host & Microbe · 2018 · 1.2K citations · Full text

, , +17

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Ioannis Mitroulis, Klara Ruppova, Baomei Wang et al. · Cell · 2018 · 1.1K citations · Full text

, , +17

1–5 of 228

Authors

1.6K

  1. MG
    Mihai G. Netea

    Radboud University Nijmegen, Netherlands

    89 publications · 19.8K citations

    52

    h-index

  2. LA
    Leo A. B. Joosten

    Radboud University Nijmegen, Netherlands

    61 publications · 16.8K citations

    43

    h-index

  3. SJ
    Simone J.C.F.M. Moorlag

    Radboud University Nijmegen, Netherlands

    31 publications · 5K citations

    28

    h-index

  4. RV
    Reinout van Crevel

    Radboud University Nijmegen, Netherlands

    29 publications · 5.9K citations

    26

    h-index

  5. LC
    L. Charlotte J. de Bree

    Radboud University Nijmegen, Netherlands

    23 publications · 2.4K citations

    21

    h-index

1–5 of 1.6K

Institutions

511

  1. Radboud University Medical Center

    Nijmegen, The Netherlands

    56 h-index

    747 publications

    196.3K citations

  2. Radboud University Nijmegen

    Nijmegen, The Netherlands

    56 h-index

    799 publications

    213K citations

  3. University of Bonn

    Bonn, Germany

    42 h-index

    90 publications

    19.4K citations

  4. Radboud Institute for Molecular Life Sciences

    Nijmegen, The Netherlands

    41 h-index

    298 publications

    82.2K citations

  5. University of Southern Denmark

    Odense, Denmark

    22 h-index

    42 publications

    7.7K citations

  6. Odense University Hospital

    Odense, Denmark

    21 h-index

    38 publications

    7.4K citations

  7. Iuliu Hațieganu University of Medicine and Pharmacy

    Cluj-Napoca, Romania

    20 h-index

    26 publications

    2.2K citations

  8. Statens Serum Institut

    Copenhagen, Denmark

    19 h-index

    41 publications

    7.8K citations

1–8 of 511

Venues

  1. Frontiers in Immunology

    36 publications · 1.7K citations

    25

    h-index

  2. Cell Reports

    15 publications · 2.3K citations

    14

    h-index

  3. The Journal of Immunology

    JI · 8 publications · 573 citations

    8

    h-index

  4. Nature Communications

    8 publications · 949 citations

    8

    h-index

  5. Journal of Leukocyte Biology

    JLB · 8 publications · 325 citations

    7

    h-index

1–5