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Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury

DOIFull Paper Access

96

Citations

56

References

2019

Year

Nicoletta Sorvillo, Daniella M. Mizurini, Carmen Coxon, Kimberly Martinod, Ronak Tilvawala, Deya Cherpokova, Ari J. Salinger, Robert Seward, Caleb Staudinger, Eranthie Weerapana,
Circulation Research

Abstract

Our data indicate that PAD4 in circulation reduces VWF-platelet string clearance and accelerates the formation of a stable platelet plug after vessel injury. We propose that this effect is, at least in part, due to ADAMTS13 inhibition.

References

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