Concepedia

CFTR-PTEN–dependent mitochondrial metabolic dysfunction promotes <i>Pseudomonas aeruginosa</i> airway infection

Sebastián A. Riquelme, Carmen Lozano, Ahmed M. Moustafa, Kalle Liimatta, Kira L. Tomlinson, Clemente J. Britto, Sara Khanal, Simren K. Gill, Apurva Narechania, José Manuel Azcona,

Science Translational Medicine · 2019 · 94 citations · 41 references

DOI

Concepts

Abstract

Excess succinate due to CFTR-PTEN dysfunction selects for Pseudomonas aeruginosa mutants adapted to the airway.

References

41

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Gillian M. Tannahill, Annie M. Curtis, Juraj Adamik et al. · Nature · 2013 · 4K citations · Full text

, , +12

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Evanna L. Mills, Beth Kelly, Angela Logan et al. · Cell · 2016 · 2.2K citations · Full text

, , +14

Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Evanna L. Mills, Dylan G. Ryan, Hiran A. Prag et al. · Nature · 2018 · 1.8K citations

, , +12

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

Vicky Lampropoulou, Alexey Sergushichev, Monika Bambousková et al. · Cell Metabolism · 2016 · 1.5K citations · Full text

, , +16

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

Bart Everts, Eyal Amiel, Stanley Ching‐Cheng Huang et al. · Nature Immunology · 2014 · 1K citations · Full text

, , +16