Repurposing drugs targeting the <scp>P2X7</scp> receptor to limit hyperinflammation and disease during influenza virus infection

Abstract

Our study demonstrates that the anti-inflammatory drugs probenecid and AZ11645373, which have documented pharmacokinetics and safety profiles in humans, are effective at dampening hyperinflammation and severe influenza disease providing potentially new therapeutic strategies for treating severe or pathogenic IAV infections.