Pyridazinones with a pendant acylsulfonamide moiety as endothelin receptor antagonists

A novel potent vasoconstrictor peptide produced by vascular endothelial cells

Masashi Yanagisawa, Hiroki Kurihara, Sadao Kimura et al. · Nature · 1988 · 10.8K citations · Full text

Life Sciences, Cell Biology, Physiology +9

Pathophysiological role of endothelin revealed by the first orally active endothelin receptor antagonist

Martine Clozel, Volker Breu, Kaspar F. Burri et al. · Nature · 1993 · 529 citations

Life Sciences, Pharmacology, Physiology +9

Pharmacological profile of FR139317, a novel, potent endothelin ETA receptor antagonist.

Keizo Sogabe, Hisataka Nirei, Miwako Shoubo et al. · Journal of Pharmacology and Experimental Therapeutics · 1993 · 222 citations

Medicine, Pharmacology, Physiology +13

Convenient procedure for the preparation of alkyl and aryl substituted N-(aminoalkylacyl)sulfonamides

James T. Drummond, Graham Johnson · Tetrahedron Letters · 1988 · 45 citations

Natural Sciences, Chemistry, Medicinal Chemistry +6

Potent dual antagonists of endothelin and angiotensin II receptors derived from α-phenoxyphenylacetic acids (Part III)

Thomas F. Walsh, Kenneth J. Fitch, David L. Williams et al. · Bioorganic & Medicinal Chemistry Letters · 1995 · 35 citations

Medicine, Medicinal Chemistry, Pharmacology +11