Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects

Christina Schindler, Hannah M. Baumann, Andreas Blum, +34

Journal of Chemical Information and Modeling

EMD 1214063 and EMD 1204831 Constitute a New Class of Potent and Highly Selective c-Met Inhibitors

Friedhelm Bladt, Bettina Faden, Manja Friese‐Hamim, +11

Clinical Cancer Research

Non-linear optical properties of hemicyanine monolayers and the protonation effect

G. Marowsky, L.F. Chi, Dietmar Möbius, +4

Chemical Physics Letters

Optical MaterialsEngineeringOptical PropertiesNon-linear OpticApplied Physics +6

Ablation of the ASCT2 (SLC1A5) gene encoding a neutral amino acid transporter reveals transporter plasticity and redundancy in cancer cells

Angelika Bröer, Gregory Gauthier-Coles, Farid Rahimi, +5

Journal of Biological Chemistry

Molecular BiologyOsteosarcoma CellsCancer BiologyTumor BiologyAmino Acid Homeostasis +16

Identification and optimization of pyridazinones as potent and selective c-Met kinase inhibitors

Dieter Dorsch, Oliver Schadt, Frank Stieber, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +5

Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa

Werner W. K. R. Mederski, Dieter Dorsch, Soheila Anzali, +3

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesMechanism Of Action +8

pH‐Dependent Binding Modes Observed in Trypsin Crystals: Lessons for Structure‐Based Drug Design

Milton T. Stubbs, Sabine Reyda, Frank Dullweber, +5

ChemBioChem

Liquid Crystals with Polar Substituents Containing Fluorine: Synthesis and Physical Properties

Ekkehard Bartmann, Dieter Dorsch, U. Finkenzeller

Molecular crystals and liquid crystals

Materials SciencePhase TransitionsEngineeringMolecule-based MaterialFluorous Synthesis +11

Influence of cation complexing solvent additives and functional groups in asymmetric alkylations of esters via lithium enolates

Günther Helmchen, Dieter Dorsch, Irmtraud Taufer

Tetrahedron Letters

Asymmetric CatalysisChemical EngineeringEngineeringLithium EnolatesOrganic Chemistry +5

Large-Scale Assessment of Binding Free Energy Calculations in Active Drug Discovery Projects

Christina Schindler, H Baumann, Andreas Blum, +34

Drug TargetEngineeringHit IdentificationBiochemistryMedicine +12