Recent advances in the synthesis of fluorinated nucleosides

Phosphorylation of 3'-azido-3'-deoxythymidine and selective interaction of the 5'-triphosphate with human immunodeficiency virus reverse transcriptase.

P A Furman, James A. Fyfe, M H St Clair et al. · Proceedings of the National Academy of Sciences · 1986 · 1.3K citations · Full text

Life Sciences, Molecular Biology, Pharmacology +8

Biosynthesis of an organofluorine molecule

David O’Hagan, Christoph Schaffrath, Steven L. Cobb et al. · Nature · 2002 · 436 citations

Life Sciences, Biochemistry, Molecular Biology +3

Uniformly modified 2'-deoxy-2'-fluoro-phosphorothioate oligonucleotides as nuclease-resistant antisense compounds with high affinity and specificity for RNA targets

Andrew M. Kawasaki, Martin D. Casper, Susan M. Freier et al. · Journal of Medicinal Chemistry · 1993 · 436 citations

Life Sciences, Molecular Biology, Bioorthogonal Chemistry +16

Methods for the synthesis of gem-difluoromethylene compounds

Matthew J. Tozer, Timothée F. Herpin · Tetrahedron · 1996 · 398 citations

Natural Sciences, Chemistry, Organic Chemistry +2

1592U89, a novel carbocyclic nucleoside analog with potent, selective anti-human immunodeficiency virus activity

Susan M. Daluge, Steven S. Good, M B Faletto et al. · Antimicrobial Agents and Chemotherapy · 1997 · 385 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15