Concepedia

Novel optimised quinuclidine squalene synthase inhibitors

George R. Brown, Alan J. Foubister, S Freeman, Fergus McTaggart, Donald J. Mirrlees, A. C. REID, Graham J. Smith, Melvyn J. Taylor, Douglas A. Thomason, Paul R. O. Whittamore

Bioorganic & Medicinal Chemistry Letters · 1997 · 15 citations · 10 references

DOI

Concepts

References

10

Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

James Shepherd, Stuart M. Cobbe, Ian Ford et al. · New England Journal of Medicine · 1995 · 7.5K citations · Full text

, , +12

Biosynthesis of isoprenoid compounds

Comparative Biochemistry and Physiology Part A Physiology · 1982 · 554 citations

, , +13

Lipophilic 1,1-bisphosphonates are potent squalene synthase inhibitors and orally active cholesterol lowering agents in vivo.

Carl P. Ciosek, David R. Magnin, Thomas Harrity et al. · Journal of Biological Chemistry · 1993 · 102 citations · Full text

, , +16

Synthesis and Activity of a Novel Series of 3-Biarylquinuclidine Squalene Synthase Inhibitors

George R. Brown, David S. Clarke, Alan J. Foubister et al. · Journal of Medicinal Chemistry · 1996 · 66 citations · Full text

, , +15

Squalene Synthase Inhibitors

Scott A. Biller, Kent Neuenschwander, Mitree M. Ponpipomt et al. · Current Pharmaceutical Design · 1996 · 63 citations

, , +16