A new protecting group for aspartic acid that minimizes piperidine-catalyzed aspartimide formation in Fmoc solid phase peptide synthesis

Deamidation, isomerization, and racemization at asparaginyl and aspartyl residues in peptides. Succinimide-linked reactions that contribute to protein degradation.

Terrence L. Geiger, Steven Clarke · Journal of Biological Chemistry · 1987 · 1.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

SIDE REACTIONS IN PEPTIDE SYNTHESIS

Miklos Bodanszky, Joseph Z. Kwei · International journal of peptide & protein research · 1978 · 146 citations

Natural Sciences, Biochemistry, Chemistry +6

Formation of aspartimide peptides in Asp-Gly sequences

Ernesto Nicolás, Enrique Pedroso, Ernest Girald · Tetrahedron Letters · 1989 · 117 citations

Life Sciences, Biochemistry, Molecular Biology +5

SIDE REACTIONS IN PEPTIDE SYNTHESIS

Jean Martínez, Miklos Bodanszky · International journal of peptide & protein research · 1978 · 95 citations

Natural Sciences, Biochemistry, Chemistry +6

Suppression of piperidine-mediated side product formation for Asp(OBut)-containing peptides by the use of N-(2-hydroxy-4-methoxybenzyl)(Hmb) backbone amide protection

Martin Quibell, David Owen, Leonard C. Packman et al. · Journal of the Chemical Society Chemical Communications · 1994 · 93 citations

Life Sciences, Biochemistry, Medicinal Chemistry +11