Cancer Cell · 2019 · 163 citations · 22 references
MedicineOncologyPharmacologyCancer ImmunologyImmunotherapyTumor ImmunologyAntitumor T Cell ResponsesCancer ImmunotherapyCheckpoint Inhibitor TherapyImmune Checkpoint InhibitorsImmune CheckpointsInflammasome ActivationAntitumor Immune ActivationCheckpoint Inhibitor AntibodiesCtla-4 SignalingCytotoxic T-lymphocyte-associated Protein 4 InhibitorsImmune Checkpoint Inhibitor ResponseImmune Checkpoint Inhibitor TherapyT Cell-mediated Tumor ControlTherapeutic Efficacy Assessment
T cell-mediated tumor control and reinforces the antitumor activity of both anti-CTLA-4 and anti-PD-1 antibodies. Thus, pharmacologic de-repression of the inflammasome by targeting TMEM176B may enhance the therapeutic efficacy of immune checkpoint blockers.
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