Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability

Non-erythroid α-spectrin breakdown by calpain and interleukin 1 β-converting-enzyme-like protease(s) in apoptotic cells: contributory roles of both protease families in neuronal apoptosis

Rathna Nath, Kadee J. Raser, Daniel Stafford et al. · Biochemical Journal · 1996 · 427 citations · Full text

Life Sciences, Biochemistry, Neuroscience +13

Upregulation of calpain activity precedes tau phosphorylation and loss of synaptic proteins in Alzheimer’s disease brain

Ksenia Kurbatskaya, Emma Claire Phillips, Cara L. Croft et al. · Acta Neuropathologica Communications · 2016 · 145 citations · Full text

Life Sciences, Neurology, Neuroscience +17

Mechanistic involvement of the calpain‐calpastatin system in Alzheimer neuropathology

Makoto Higuchi, Nobuhisa Iwata, Yukio Matsuba et al. · The FASEB Journal · 2011 · 104 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Specific Calpain Inhibition by Calpastatin Prevents Tauopathy and Neurodegeneration and Restores Normal Lifespan in Tau P301L Mice

Mala V. Rao, MaryKate McBrayer, Ashok Kumar et al. · Journal of Neuroscience · 2014 · 98 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17

Calpain Inhibitor A-705253 Mitigates Alzheimer's Disease–Like Pathology and Cognitive Decline in Aged 3xTgAD Mice

Rodrigo Medeiros, Masashi Kitazawa, Meredith A. Chabrier et al. · American Journal Of Pathology · 2012 · 91 citations

Medicine, Neuroscience, Pharmacology +17