Achim Moeller

Calpain Inhibitor A-705253 Mitigates Alzheimer's Disease–Like Pathology and Cognitive Decline in Aged 3xTgAD Mice

Rodrigo Medeiros, Masashi Kitazawa, Meredith A. Chabrier et al. · American Journal Of Pathology · 2012 · 91 citations

Medicine, Neuroscience, Pharmacology +17

The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons

Roxana C. Sinjoanu, Sara Kleinschmidt, Robert S. Bitner et al. · Neurochemistry International · 2008 · 45 citations

Life Sciences, Neurobiology, Neuroscience +17

Discovery of Novel and Highly Selective Inhibitors of Calpain for the Treatment of Alzheimer’s Disease: 2-(3-Phenyl-1<i>H</i>-pyrazol-1-yl)-nicotinamides

Andreas Kling, Katja Jantos, Helmut Mack et al. · Journal of Medicinal Chemistry · 2017 · 34 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16

The novel calpain inhibitor A-705253 prevents stress-induced tau hyperphosphorylation in vitro and in vivo

Arthur L. Nikkel, Brenda Martino, Stella Markosyan et al. · Neuropharmacology · 2012 · 29 citations

Life Sciences, Biochemistry, Molecular Biology +4

Discovery of ABT-957: 1-Benzyl-5-oxopyrrolidine-2-carboxamides as selective calpain inhibitors with enhanced metabolic stability

Katja Jantos, Andreas Kling, Helmut Mack et al. · Bioorganic & Medicinal Chemistry Letters · 2019 · 21 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12