Concepedia

Diverse compounds from pleuromutilin lead to a thioredoxin inhibitor and inducer of ferroptosis

Evijola Llabani, Robert W. Hicklin, Hyang Yeon Lee, Stephen E. Motika, Lisa A. Crawford, Eranthie Weerapana, Paul J. Hergenrother

Nature Chemistry · 2019 · 226 citations · 49 references

DOI

Concepts

References

49

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon, Kathryn M. Lemberg, Michael R. Lamprecht et al. · Cell · 2012 · 18.1K citations · Full text

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Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang, Rohitha Sriramaratnam, Matthew Welsch et al. · Cell · 2014 · 7.5K citations · Full text

, , +12

Escape from Flatland: Increasing Saturation as an Approach to Improving Clinical Success

Frank Lovering, Jack Bikker, Christine Humblet · Journal of Medicinal Chemistry · 2009 · 4.4K citations

, , +8

A Next Generation Connectivity Map: L1000 Platform and the First 1,000,000 Profiles

Aravind Subramanian, Rajiv Narayan, Steven M. Corsello et al. · Cell · 2017 · 3.7K citations · Full text

, , +16

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

Scott J. Dixon, Darpan N. Patel, Matthew Welsch et al. · eLife · 2014 · 2.1K citations · Full text

, , +13