Relationship of nutrigenomics and aging: Involvement of DNA methylation

Abstract

Complex epigenetic mechanisms are involved in aging and longevity. Nutrition has a strong impact upon epigenetic processes and, therefore, holds promising roles in regulation of longevity and aging. In this review, we combine recently published information regarding nutrition and its impact on epigenetically mediated mechanisms involved in metabolic responses that lead to aging in a narrative way with questions and future directions at the end of each section. The paper strictly focuses on modulation of DNA methylation (DNAm) by nutrients, and its role in regulation of aging process. Understanding the mechanisms by which nutrition influences epigenome is crucial for the development of preventive and interventional strategies to increase well-being and health for a sustainable longevity.