Concepedia

Aging-associated Epigenetic Changes

Aging-Associated Epigenetic Changes is a biological phenomenon characterized by progressive, age-dependent alterations in epigenetic marks—such as DNA methylation, histone modifications, and chromatin remodeling—that cumulatively affect gene expression patterns and genomic stability over an organism's lifespan.

1.5K

Publications

129.7K

Citations

9.3K

Authors

2.2K

Institutions

Publications per year

2017–2026

900

Variants

Age-related Epigenetic Changes

Parents

Publications

1.5K

An epigenetic biomarker of aging for lifespan and healthspan

Morgan E. Levine, Ake T. Lu, Austin Quach et al. · Aging · 2018 · 3.6K citations · Full text

, , +17

Gene regulation and DNA damage in the ageing human brain

Tao Lu, Ying Pan, Shyan‐Yuan Kao et al. · Nature · 2004 · 1.9K citations

, , +16

Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

Raúl Mostoslavsky, Katrin F. Chua, David B. Lombard et al. · Cell · 2006 · 1.6K citations · Full text

, , +16

Evolutionarily Conserved and Nonconserved Cellular Localizations and Functions of Human SIRT Proteins

Eriko Michishita, Jean Y. Park, Jenna M. Burneskis et al. · Molecular Biology of the Cell · 2005 · 1.4K citations · Full text

, , +16

Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context

Brock C. Christensen, E. Andrés Houseman, Carmen J. Marsit et al. · PLoS Genetics · 2009 · 1.1K citations · Full text

, , +17

1–5 of 1.5K

Authors

9.3K

  1. SH
    Steve Horvath

    University of California, Los Angeles, United States

    114 publications · 19.7K citations

    60

    h-index

  2. RE
    Riccardo E. Marioni

    University of Edinburgh, United Kingdom

    33 publications · 3K citations

    25

    h-index

  3. AT
    Ake T. Lu

    University of California, Los Angeles, United States

    31 publications · 8.7K citations

    22

    h-index

  4. AB
    Andrea Baccarelli

    Harvard University, United States

    28 publications · 7.2K citations

    22

    h-index

  5. ME
    Morgan E. Levine

    Yale University, United States

    25 publications · 7.4K citations

    22

    h-index

1–5 of 9.3K

Institutions

2.2K

  1. University of California, Los Angeles

    Los Angeles, United States

    68 h-index

    433 publications

    86.3K citations

  2. Harvard University

    Cambridge, United States

    55 h-index

    453 publications

    108.6K citations

  3. National Institutes of Health

    Bethesda, United States

    44 h-index

    252 publications

    45.4K citations

  4. Stanford University

    Stanford, United States

    37 h-index

    207 publications

    36.2K citations

  5. National Institute on Aging

    Baltimore, United States

    33 h-index

    172 publications

    28.7K citations

  6. Brigham and Women's Hospital

    Boston, United States

    32 h-index

    172 publications

    24K citations

  7. Columbia University

    New York, United States

    30 h-index

    105 publications

    15.7K citations

  8. Johns Hopkins University

    Baltimore, United States

    28 h-index

    116 publications

    15.5K citations

1–8 of 2.2K

Venues

  1. Aging Cell

    77 publications · 8.8K citations

    49

    h-index

  2. Aging

    75 publications · 10.2K citations

    41

    h-index

  3. Clinical Epigenetics

    49 publications · 3.2K citations

    31

    h-index

  4. Nature Communications

    36 publications · 4.1K citations

    31

    h-index

  5. Scientific Reports

    34 publications · 2.3K citations

    25

    h-index

1–5