Inhibition of cyclin-dependent kinases by AT7519 is effective to overcome chemoresistance in colon and cervical cancer

Epigenetic and genetic features of 24 colon cancer cell lines

D. Ahmed, Peter W. Eide, Ina A. Eilertsen et al. · Oncogenesis · 2013 · 906 citations · Full text

Medicine, Molecular Genetics, Oncology +17

Identification of <i>N</i>-(4-Piperidinyl)-4-(2,6-dichlorobenzoylamino)-1<i>H</i>-pyrazole-3-carboxamide (AT7519), a Novel Cyclin Dependent Kinase Inhibitor Using Fragment-Based X-Ray Crystallography and Structure Based Drug Design

Paul G. Wyatt, Andrew Woodhead, Valério Berdini et al. · Journal of Medicinal Chemistry · 2008 · 341 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

CDK9-dependent RNA polymerase II pausing controls transcription initiation

Saskia Gressel, Björn Schwalb, Tim-Michael Decker et al. · eLife · 2017 · 251 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines

Matthew Squires, Ruth E. Feltell, Nicola G. Wallis et al. · Molecular Cancer Therapeutics · 2009 · 172 citations

Medicine, Medicinal Chemistry, Oncology +15

AT7519, A novel small molecule multi-cyclin-dependent kinase inhibitor, induces apoptosis in multiple myeloma via GSK-3β activation and RNA polymerase II inhibition

Loredana Santo, Sonia Vallet, Teru Hideshima et al. · Oncogene · 2010 · 144 citations · Full text

Medicine, Cancer Biology, Oncology +17