Concepedia

The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition

Judith Hounjet, R. Habets, Marco B.E. Schaaf, Tessa C. Hendrickx, Lydie M.O. Barbeau, Sanaz Yahyanejad, Kasper M.A. Rouschop, Arjan J. Groot, Marc Vooijs

Oncogene · 2019 · 31 citations · 49 references

DOI

Concepts

References

49

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

The EMBO Journal · 2000 · 6.5K citations · Full text

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DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Christopher J. Bakkenist, Michael B. Kastan · Nature · 2003 · 3.4K citations

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Activating Mutations of <i>NOTCH1</i> in Human T Cell Acute Lymphoblastic Leukemia

Andrew P. Weng, Adolfo A. Ferrando, Woojoong Lee et al. · Science · 2004 · 2.7K citations

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A monomeric red fluorescent protein

Robert E. Campbell, Oded Tour, Amy E. Palmer et al. · Proceedings of the National Academy of Sciences · 2002 · 2.4K citations · Full text

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Autophagy promotes tumor cell survival and restricts necrosis, inflammation, and tumorigenesis

Kurt Degenhardt, Robin Mathew, Brian Beaudoin et al. · Cancer Cell · 2006 · 2K citations · Full text

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