Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins

Arjan J. Groot, R. Habets, Sanaz Yahyanejad, +4

Molecular and Cellular Biology

Transcriptional RegulationProtein FunctionSignal TransductionDevelopmental BiologySignaling Pathway +11

NOTCH blockade combined with radiation therapy and temozolomide prolongs survival of orthotopic glioblastoma

Sanaz Yahyanejad, Henry King, Venus Sosa Iglesias, +12

Oncotarget

Notch BlockadeHigh-grade GliomasCancer BiologyGliomaTumor Biology +16

High NOTCH activity induces radiation resistance in non small cell lung cancer

Jan Theys, Sanaz Yahyanejad, R. Habets, +9

Radiotherapy and Oncology

Tumor BiologyRadiation TherapyMedicineRadiation OncologyOncology +5

Human NOTCH2 Is Resistant to Ligand-independent Activation by Metalloprotease Adam17

R. Habets, Arjan J. Groot, Sanaz Yahyanejad, +3

Journal of Biological Chemistry

Multi-modal effects of 1B3, a novel synthetic miR-193a-3p mimic, support strong potential for therapeutic intervention in oncology

Bryony J. Telford, Sanaz Yahyanejad, Thijs de Gunst, +8

Oncotarget

The anti-malarial drug chloroquine sensitizes oncogenic NOTCH1 driven human T-ALL to γ-secretase inhibition

Judith Hounjet, R. Habets, Marco B.E. Schaaf, +6

Oncogene

Anti-malarial Drug ChloroquineMedicineMalariaImmunologyMechanism Of Action +3

An image guided small animal radiation therapy platform (SmART) to monitor glioblastoma progression and therapy response

Sanaz Yahyanejad, Stefan J. van Hoof, Jan Theys, +5

Radiotherapy and Oncology

Neuro-oncologyMedical ImagingRadiation TherapyMedicineTherapy Response +12

Complementary Use of Bioluminescence Imaging and Contrast-Enhanced Micro—Computed Tomography in an Orthotopic Brain Tumor Model

Sanaz Yahyanejad, Patrick V. Granton, Natasja G. Lieuwes, +6

Molecular Imaging

Transcriptome-wide analysis reveals insight into tumor suppressor functions of 1B3, a novel synthetic miR-193a-3p mimic

Marion T.J. van den Bosch, Sanaz Yahyanejad, Mir Farshid Alemdehy, +8

Molecular Therapy — Nucleic Acids

Phase I/Ib study with INT-1B3, a novel LNP-formulated micro-RNA (miR-193a-3p mimic) therapeutic for patients with advanced solid cancer.

Nuria Kotecki, Frans L. Opdam, Debbie Robbrecht, +12

Journal of Clinical Oncology

EngineeringTps2666 BackgroundImmunologyImmunotherapeuticsCancer Biology +21